TH17 cell flavors

Th17 cell function and Th17-mediated autoimmune disease

© 2008 Pappu et al. The Rockefeller University Press $30.00 J. Exp. Med. Vol. 205 No. 5 1049-1062 www.jem.org/cgi/doi/ 1049 10.1084/jem.20071364 After activation, CD4 + Th cells diff erentiate into distinct eff ector subsets that are characterized by their unique cytokine expression and immunoregulatory function ( 1, 2 ). A novel Th subset — termed Th IL-17 , Th17, or infl ammatory Th — has bee...

Estradiol Inhibits Th17 Cell Differentiation

Sox5 and Th17 cell differentiation

Sox (SRY-related high-mobility-group (HMG)-box) transcription factors, which are comprised of 20 genes containing a conserved HMG DNA-binding domain, are divided into 8 groups (from A to H) according to structural homologies [reviewed in 1-2]. SoxC group, which is composed of Sox4, Sox11, and Sox12, has a HMG box domain and a transactivation domain and plays important roles in the development o...

Heavy Flavors*

Working Group Members: A. Abashian, Y. Arad, V. Barger, B. Barnett, D. Berley, C. Bromberg, C. Buchanan, J. Butler, L. Chau, J. Collins B. Cox, N. Deshpande, I. Dunietz, G. Feldman, F. Gilman, N. Glover, T. Gottschalk, G. Hanson, D. Hedin, S. Heppelmann, L. Jones, D. Judd, H. Kagan, J. Merlo, B. Milliken, M. Mishina, D. Morris, A. Odian, F. Paige, R. Panvini, L. Price, J. Ralston, D. Reeder, R....

Transcriptional regulatory networks in Th17 cell differentiation.

Upon encountering antigen in the context of antigen presenting cells, naïve CD4(+) T cells undergo differentiation into effector T helper (Th) cells, which can secrete high levels of cytokines and other immunomodulators to mediate host defense and tissue inflammation. During the past three years, the immunology field has witnessed an explosion of research advances in the biology of Th17 cells, ...